DrugPair interaction guide

Atorvastatin and Grapefruit

Atorvastatin (Lipitor) is a statin used to lower cholesterol. Grapefruit and grapefruit juice can increase the amount of atorvastatin in your blood, raising the risk of side effects.

Moderate interaction

Use with caution — ask your doctor or pharmacist.

What you need to know

Grapefruit contains compounds that block a liver enzyme (CYP3A4) responsible for breaking down atorvastatin. When this enzyme is blocked, more atorvastatin stays in your bloodstream, potentially raising the risk of muscle breakdown and liver problems. Large quantities of grapefruit should be avoided.

What to do

Avoid large amounts of grapefruit or grapefruit juice — more than one glass per day.

Pomelo and Seville oranges also contain similar compounds.

If you love grapefruit, ask your doctor about switching to a statin less affected by it.

When to call your doctor

Unexplained muscle pain, tenderness, or weakness.

Dark-coloured urine — a sign of muscle breakdown.

Sources:FDANIH MedlinePlusAmerican Heart Association

DrugPair provides educational safety information only and is not a substitute for professional medical advice. Always ask a doctor or pharmacist before changing medicines, supplements, food, drinks, or prescription timing.

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