DrugPair interaction guide

Warfarin and Ibuprofen

Warfarin is a blood thinner. Ibuprofen (Advil, Motrin) is an NSAID pain reliever. Taking them together raises your bleeding risk significantly.

Major interaction

Do not combine without direct medical supervision.

What you need to know

Ibuprofen can increase the blood-thinning effect of warfarin and irritate the stomach lining, raising the risk of gastrointestinal bleeding. Even short-term use can be dangerous. Most pharmacists recommend acetaminophen (Tylenol) as the safer pain-relief choice for people on warfarin.

What to do

Avoid ibuprofen and other NSAIDs while taking warfarin unless your doctor has specifically approved it.

Use acetaminophen (Tylenol) for mild pain — it is generally safer with warfarin at recommended doses.

Tell every healthcare provider and pharmacist you are on warfarin before taking any new medicine.

When to call your doctor

Unusual bruising, bleeding gums, blood in urine or stool, or prolonged bleeding from cuts.

Any stomach pain or black, tarry stools.

If you accidentally took ibuprofen while on warfarin.

Severe symptoms? Call 911 (US) or Poison Control 1-800-222-1222

Sources:FDANIH MedlinePlusAmerican Heart Association

DrugPair provides educational safety information only and is not a substitute for professional medical advice. Always ask a doctor or pharmacist before changing medicines, supplements, food, drinks, or prescription timing.

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